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Screenshot 2024-03-01 at 13.51_edited.pn
Screenshot 2024-03-01 at 13.51_edited.pn

Surface Biofunctionalisation

Tailored and molecularly defined surfaces that mimic selected aspects of biological interfaces

Screenshot 2024-03-01 at 13.51_edited.pn

Surface biofunctionalisation enables the bottom-up assembly of biomacromolecules such as lipids, proteins and glycans in vitro into supramolecular architectures with well-defined and tunable complexity and physico-chemical properties.

surface biofunctionalisation examples.pn

​Surfaces created through this technique will replicate selected structural, biochemical and physical characteristics of real biological interfaces, such as the cell surface. Such biomimetic surfaces enable quantitative analyses of biomolecular and cellular interactions that are not possible with real cells, owing to a reduced complexity and increased control in biomolecule presentation.

Applications in our research 

Surface biofunctionalisation is a versatile tool used across much of our current research.​ To learn more, please click any of the below icons. 

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Competitive specific anchorage of molecules onto surfaces: Quantitative control of grafting densities and contamination by free anchors

O. Kirichuk, S. Srimasorn, X. Zhang, A. R. E. Roberts, L. Coche-Guerente, J. C. F. Kwok, L. Bureau, D. Débarre and R. P. Richter Langmuir 2023, 39:18410–18423

Formation of solid-supported lipid bilayers:
An integrated view

R. Richter, R. Bérat and A. Brisson Langmuir, 2006, 22:3497-3505.

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