Quartz crystal microbalance with dissipation monitoring (QCM-D)
Monitor binding processes at surfaces,
and changes in the stiffness and morphology of interfacial films
QCM-D is a real-time and label-free sensing technique that responds to changes in the mass and viscoelastic properties of surface-confined biomolecular films. It achieves this by detecting changes in the resonance frequency and energy dissipation of a piezoelectric sensor. To a first approximation, frequency shifts relate to mass changes, and dissipation shifts reflect on the softness of the film. From the QCM-D response, the thickness and viscoelastic properties of surface-adhering soft films can be quantified.
Applications in our research
QCM-D is a versatile tool to analyse biomolecular interactions and biomolecular films at surfaces. It is used across much of our current research; to learn more, please click any of the below icons.
